| Effect of Blood Flow Restriction Training Versus Electrical Muscle Stimulation on Muscle Atrophy Signaling Pathway in Elite Male Athletes Following Anterior Cruciate Ligament Surgery |
| Paper ID : 1127-SSRC-13TH |
| Authors |
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Abozar Alavi1, Najmeh Rezaeian *2, Reza Ganji3, Ali Yaghoubi4 1واحد بجنورد، دانشگاه آزاد اسلامی، بجنورد، ایران 2Department of physical education, Bojnourd branch, Islamic Azad University, Bojnourd, Iran 33. گروه جراحی ارتوپدی، دانشگاه علوم پزشکی خراسان شمالی، بجنورد، ایران 4گروه تربیت بدنی، واحد بجنورد، دانشگاه آزاد اسلامی، بجنورد، ایران |
| Abstract |
| Aim and Background: The cellular mechanisms preventing muscle atrophy after Anterior Cruciate Ligament (ACL) regeneration are not well understood. Porpuse of this study was to investigate the effects of blood flow restriction (BRF) and electrical stimulation (EMS) on serum levels of silent information regulator T1 (SIRT1), muscle ring finger 1 (MURF1) and atrogin-1 in elite male athletes after ACL reconstruction surgery. Methodology: Thirty elite male athletes after anterior cruciate ligament surgery were selected and randomly divided into three groups of 1) BRF, 2) EMS and 3) control groups (10 subjects in each group). The subjects in BRF group performed resistance training with cuff pressure on the proximal part of the thigh with 120-180 mmHg for 12 weeks. However, The subjects in EMS group performed 12 weeks of resistance training along with electrical stimulation at frequency of 35-70 Hz. The subjects in control group participated in 12 weeks of resistance training [2-4 sets, at intensity of 30-70 percent of 10 repetition maximum (RM)] without no intrvention else. Blood factors were assessed before and 48 hours following last training session. Statistical analysis was done by analysis of Covariance and paired t-test at significant level of P<0.05. Results: There were significant differences between training groups of BFR and EMS and control groups in SIRT1 (P=0.00) and atrogin-1 (P=0.032, P=0.03, respectively) concentrations. Moreover, twelve weeks of BRF and EMS resulted to significant increases in serum levels of SIRT1 (P=0.00) and significant decreases in atrogin-1 (P=0.013, P=0.01, respectively) and MURF1 (P=0.035, P=0.008, respectively) levels compared to pre-test. Conclusion: Overall, it seems that both of EMS and BRF are more effective protocols compared to traditional resistance training to improve muscle atrophy following disuse and injury in elite athletes. |
| Keywords |
| Blood Flow Restriction, Electrical Muscle Stimulation, MURF1, Atrogin-1, Anterior Cruciate Ligament Injury. |
| Status: Abstract Accepted (Oral Presentation) |
