| The effect of 12 weeks of exercise training on TGF-β1 levels in patients with MS |
| Paper ID : 1143-SSRC-13TH |
| Authors |
|
Azam Mollanovruzi1, Mitra Khademosharie *2 1Department of Sport Sciences, Faculty of Humanities, Kosar University of Bojnord, Iran 2Assistant Professor, Department of Sport Sciences, Faculty of Humanities, Kosar University of Bojnord, Iran |
| Abstract |
| Background and Purpose: Multiple sclerosis is an inflammatory and chronic central nervous system with unknown etiology. MS is often associated with some symptoms (eg, fatigue and depression) and dysfunction (eg, mobility and cognitive impairment), which often affects the quality of life and participation in everyday life activities negatively. Despite much attempt made by researchers, there is no definitive medical treatment for MS, with the currently available medications and treatments being only effective in relieving its side effects, and in preventing its recurrent attacks. Physical activity, particularly exercise training, is an evidence-based approach for managing symptoms, restoring function and improving overall wellness in people with multiple sclerosis (MS). The purpose of this study was to evaluate the effect of 12 weeks of endurance and resistance training on TGF-β1 levels in patients with, considering the positive effects of exercise in these patients and the lack of information on combined exercises. Methods: Twenty 20-50 years old women participated and were divided into 2 comparable groups of control (n=10) and experimental (n=10) based on their multiple sclerosis and the disability grade of 2-5 (EDSS). Afterwards, the subjects participated in the training programs for twelve weeks, 3 sessions/week. Results: Data were analyzed using with Repeated Measure ANOVA (α=0.05). The results revealed no difference on body weight and fat percentage. Although, exercise training significantly decreased the disability grade (P=0/002). Furthermore, exercise training did not illustrate any change in TGF-β1 (P= 0/46) serum. Conclusion: Comparison between the control and experimental groups revealed that the 12 weeks of endurance and resistance training would be a good option to enhance disability grade in multiple sclerosis patients. However, it revealed no effect on the inflammatory and biochemical indicators associated with this disease. |
| Keywords |
| Exercise Training, MS, TGF-β1 |
| Status: Abstract Accepted (Poster Presentation) |
