| Effect of high-intensity interval training (HIIT) on chemerin and insulin resistance in rats with non-alcoholic fatty liver Disease |
| Paper ID : 1176-SSRC-13TH |
| Authors |
|
Ali Yaghoubi *, reza rahimi Department of Physical Education and Sport Science, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran |
| Abstract |
| Introduction: Chemerin is secreted from visceral adipose tissue and liver and plays an important role in macrophage recruitment to adipose tissue, development of inflammation, and insulin resistance, leading to insulin stimulation and increased glucose uptake in adipocytes. Thus, the present study aimed to investigate the effect of high-intensity interval training (HIIT) on chemerin plasma level and insulin resistance in rats with non-alcoholic fatty liver disease (NAFLD). Materials and Methods: 40 male Wistar rats (8 weeks old), divided into 4 groups including, healthy control (HC), healthy training (HT), fatty liver control (FLC), and fatty liver training (FLT). NAFLD induced with high-fat diet (60% fat) for 12 weeks. After estimating the maximum speed, rats in the training groups, HT and FLT groups participated in 8 weeks of HIIT of running on the treadmill 5-8 sets of running for 2 minutes at an intensity of 80-100 VO2Max with rest intervals of running for 2 minutes at an intensity of 50 VO2Max, 5 sessions per week for 8 weeks. Plasma samples were extracted 48 hours after the last training session to measure protein levels of chemerin, glucose, insulin, and insulin resistance. One-way ANOVA and Tukey post hoc test were used for data analysis. Results: Plasma chemerin levels in FLC were significantly higher than HC and HT groups (p=0.001). chemerin level in FLT was significantly lower than FLC (p=0.01). Insulin resistance in FLC was significantly higher than HC and HT groups (p-value respectively 0.011 and 0.009). Insulin resistance in FLT was significantly lower than FLC (p=0.044). Conclusion: It seems that HIIT reducing chemerin, reduce insulin resistance in NAFLD. Thus HIIT can be an effective step towards controlling and reducing the risk factors in NAFLD. |
| Keywords |
| High-Intensity Interval Training, Chemerin, Insulin Resistance, Non-Alcoholic Fatty Liver Disease |
| Status: Abstract Accepted |
