| Evaluation of KATP response on protection of heart tissue in male rats after resistance training |
| Paper ID : 1184-SSRC-13TH |
| Authors |
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fatemeh ahmadi *1, shadmehr mirdar2, masome nobahar1 1department of physical education and sport science,payame noor university,tehran,iran 2department of exercise physiology ,faculty of sport science, university of mazandaran,babolsar,iran |
| Abstract |
| Background: Due to the widespread global prevalence of coronary artery disease, it is important to provide a strategy to protect the heart from injury. Increasing the function of ATP-sensitive potassium channels is a specific mechanism of heart protection that is achieved through regular exercise. Research has shown that physical activity exerts its vasodilatory effect mainly in the coronary artery through calcium-sensitive potassium channels, as well as the presence of different subunits of ATP-sensitive potassium channels required for vasodilating effects in sports vessels. Is Objective: The aim of this study was to evaluate the KATP response of ATP-sensitive potassium channels to the protection of heart tissue in male rats after eight weeks of resistance training. Methodology: The present study was an experimental study consisting of 10 healthy male Wistar rats with a mean weight of 150 70 70 which were randomly divided into control and resistance training groups. The resistance training group performed the training protocol for 8 weeks. For immunohistochemical tests, the heart tissue was measured and the level of potassium channel proteins (KIR6.2, SUR) in the left ventricle of the tissue was measured. Independent t-test was used to analyze the data. Significance level was considered less than 0.05. Results: After 8 weeks of resistance training, it was shown that the expression of potassium channel proteins (KIR6.2, SUR) in the resistance training group was higher than the control group (P = 0.001). Conclusion: It seems that resistance training by manipulating the ATP mechanism increases the number of ATP-sensitive potassium channels in the heart tissue, which ultimately leads to a reduction in tissue damage |
| Keywords |
| Keywords: Resistance training, Potassium channel, Heart tissue |
| Status: Abstract Accepted (Poster Presentation) |
