| The effects of aerobic training on bone mineral density in type 2 diabetic rats |
| Paper ID : 1727-SSRC-13TH |
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Oral / Poster Presentation File |
| Authors: |
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abbas saremi * 1. Associate Professor, Department of Exercise Physiology, Faculty of Sport Sciences, Arak University, Arak, Iran |
| Abstract: |
| Introduction: Aerobic training (AT) has been known to be effective in maintaining and improving bone strength, which is based on bone mineral density (BMD) and bone quality. However, it is not clear whether AT is effective in improving bone strength in patients with type-2 diabetes mellitus (T2DM), who have a high risk of fracture. Therefore, we tested the effects of a 12-week AT regimen in T2DM model rats. Methods: Thirty-six male Wistar rats (14 weeks old) were randomly allocated into three groups including diabetic training (DT) group, diabetic (D) group and control (C) group. At fifteen weeks-of-age, diabetes was induced by an intraperitoneal injection of Nicotinamide-Streptozotocin. Rats in the DAT group carried out an 12-week exercise program on a motorized treadmill (27 m/min for 20-60 min/day), whereas the C and DC remained sedentary in their cages. Body composition and bone density throughout the body were assessed using a dual X-ray energy absorption at the beginning and after the intervention. Data were analyzed using SPSS statistical software and one-way analysis of variance and Tukey post hoc tests. Results: At the end of the intervention period, bone mineral density in the thigh and lumbar spine were significantly lower in DT and D groups compared with C group (P<0.01). Bone density in the thighs and lumbar spine were significantly lower in D group compared with DT and C group (p < 0.05). Conclusion: These results indicate that the 12-week AT regimen effectively increased BMD and improved bone quality in T2DM model rats. Our findings suggest that AT may have the potential to improve bone strength and reduce fracture risk, even in patients with T2DM. |
| Keywords: |
| Bone mass, bone quality, resistance training, type-2 diabetes mellitus |
| Status : Abstract Accepted (Oral Presentation) |