| Comparison of different intensities of exercise on IP-10 gene expression in the male adult rats |
| Paper ID : 1737-SSRC-13TH |
| Authors |
|
Elham Vosadi *, Marzieh Amirsalary, Farhad Gholami Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Shahroud University of Technology, Semnan, Iran |
| Abstract |
| One of the controversial topics that have attracted the attention of experts is the effects of different methods and intensities of exercise on the immune system. Interferon gamma-induced protein 10 (IP-10) is a small cytokine involved in the chemical uptake of certain immune system factors such as monocytes/ macrophages and T cells. The aim of this study was to investigate the effect of different intensities of interval training on IP-10 gene expression in adult male rats. In this study, twenty-four rats were divided into three groups: (1) High-intensity Training, (2) Low-intensity Training, and (3) Control groups. Training groups trained for 8 weeks and 5 days a week. The HIT group exercise program consists of running on a treadmill with five alternatives (8 minutes with 85-90% VO2max intensity and 2 minutes 50-60% VO2max intensity) and the LIT group exercise program is included five alternatives (8 minutes with 55-60% VO2max intensity and 2 minutes 45-50% VO2max intensity), that did a specific hour of the day and at the same time, the control group had no exercise. The expression of the IP-10 gene was measured in the soleus muscle. The data were analyzed by one-way ANOVA and Tukey post hoc test and statistical differences were considered significant at P<0.05. The results of this study showed that the expression levels of the IP-10 gene in the HIT group were significantly higher than the control group (P = 0.01, P = 0.04), while the levels of the IP-10 gene in the LIT groups were not significantly different than the control group (P = 0.2, P = 0.1). According to the results of the present study, it seems that High-intensity exercise can be more effective than low intensity in increasing immunity, which is dependent on IP-10 levels. |
| Keywords |
| Interferon gamma-induced protein 10, High-intensity Training, Low-intensity Training, male adult rat. |
| Status: Abstract Accepted (Poster Presentation) |
