| The effect of swimming exercise on memory impairment and inflmmatory eytokines TNF_ α and IL_1 and induced by lipopolysaccharide in male mice |
| Paper ID : 1856-SSRC-13TH |
| Authors |
|
khadijeh khazaei * Payame Noor University, South Tehran Branch |
| Abstract |
| The present study investigated the effect of 8-weeks of swimming training on memory impairment and inflammatory satiokines TNFα and IL1 induced by lipopolysaccharide injection in male mice. The statistical population of this study is 40-NMIR mice with an approximate age of 70-days and a weight of 23 ± 1. The research method is experimental. The animals were randomly selected and divided into four groups. first group; They did not exercise and received saline. The second group; They did not exercise and received lipopolysaccharide. Third group; They exercised and received saline. Fourth group; The animals exercised and received lipopolysaccharide. The training program consisted of two swimming stages (adaptive and swimming stage). In the first week, to reduce the stress of animals caused by swimming, mice swam in 5-cm shallow water for 10-minutes, which were placed to adapt to the method. The swimming phase consists of two or three 10-minute training sessions with a 10-minute rest interval in the second week and a water depth of 10-cm between each session. Water depth and swimming duration gradually increased from 5 to 15 cm and from 20-minutes in the second week to 30-minutes from the third week (water depth 15-cm and three halves of 10-minutes of swimming, 10-minutes of rest) and from this week onwards the day . This training protocol was performed every day between 13:00 and 16:00 at the same time. After 9-days of training sessions, they received lipopolysaccharide and animal behavioral tests were taken on the first, second and third days. Behavioral tests were used to assess cognitive function and spontaneous periodicity that indicated memory: The YMAZ-TMAZ-new object detection tests were used. For data analysis, Kolmogorov-Smirnov test was used to measure the normality of data distribution and two-way analysis of variance was used to compare the desired variables (practiced-without practice). Using SPSS26 software and a significance level of less than P <0.05 was obtained. The results of this study showed that lipopolysaccharide reduces spontaneous frequency and memory. And swimming increases memory function and spontaneous rotation. the overall results of this study showed that swimming has an anti-inflammatory effect and improves memory. |
| Keywords |
| swimming exercise- memory- inflammation- oxidative stress- cytokine |
| Status: Abstract Accepted (Oral Presentation) |
